Our Research
At the core of the lab’s mission is a fundamental question:
How do cells orchestrate complex, coordinated biochemical events to adapt to ever-changing environments, and what happens when this coordination fails in diseases like cancer?
To answer this, the team harnesses generative AI to create with unprecedented specificity and modularity molecular tools such as biosensors, proximity labelers, activators, and inhibitors.
This cutting-edge molecular engineering approach is revolutionizing biology by enabling the creation of entirely novel proteins that nature has not evolved. With these AI-engineered molecules, the lab is both expanding the toolkit of cell biology and tackling urgent clinical challenges, from decoding cancer signaling to developing next-generation precision therapeutics.
Structure-based AI programs to design binders to diverse targets.
AI-designed biosensor expressed in a cancer cell to track cancer signaling throughout space and time.